Case study
User Testimonials and Success Stories
We work closely with our customers from across the globe to ensure they get the best from SpotMap MS.
To help you to evaluate SpotMap MS for your projects we can provide you with a demonstration of the software using your own images from your own lab and fully support you throughout a free trial of the software.
Welcome to our comprehensive resource showcasing real-world case studies, posters, application notes, and technical evidence demonstrating how the SpotMap MS software from TotalLab supports accurate, reproducible and automated host cell protein (HCP) anylsis via LC-MS. Learn how laboratories worldwide rely on SpotMap MS to accelerate their data analysis, improve quality control, and reduce inter-user variability.
Key Benefits Highlight
- Fast, reliable HCP analysis: See how SpotMap MS compares and outperforms other methods in time and accuracy.
- Proven reproducibility: Studies from leading institutions highlight low inter-user and inter-lab variation giving you much greater confidence in your data.
- Regulatory compliance: SpotMap MS can be made fully 21 CFR Part 11 and GMP compliant when combined with our AuditSafe software.
- Trusted by experts: Read testimonials and case studies from global research labs and pharmaceutical companies.
Case Studies (Click to Enlarge)
Developing a High-Throughput Host Cell Protein Analysis Workflow with Novel SpotMap MS Software – Presented at CASSS Mass Spectrometry Conference 2025
“Spotmap MS is used for data processing as it is fast and gives the user more control in evaluating potential peptide identifications”
Chris Sauer, Johnson and Johnson
The Total HCP Project with Novel SpotMap MS Software – Presented at BEBPA HCP Conference 2024
Interested in experiencing SpotMap MS for your lab? Request a free software demonstration or start your trial today to see how TotalLab can transform your host cell protein analysis workflow.
Keep reading
All SpotMap MS resources →- GuideHost Cell Protein Resource Hub: Methods, Limits and SoftwareOne starting point for host cell protein analysis. How ELISA, 2D gel and LC-MS compare, where each method stops working, what regulators actually require, and which questions to settle before you choose a platform. Links to every guide in the series, and to SpotMap MS for LC-MS and SpotMap 2D for gel-based coverage.
- GuideAAV Host Cell Protein Analysis: Why mAb Methods FailAAV and lentiviral vector processes break the assumptions mAb HCP methods rely on: no null cell line, a capsid as the product protein, helper and packaging proteins in the mix, and no agreed ppm basis. This resource sets out what to measure instead and what to ask of an LC-MS workflow before you adopt one for gene therapy products.
- ComparisonDIA vs DDA for HCP Analysis: Reproducibility ExplainedDDA re-picks precursors on every injection, so low-abundance host cell proteins appear and vanish between runs. DIA fragments every window. This resource explains what that means for HCP reproducibility and ppm trending, and what to ask of your analysis software before you commit to either.
SpotMap MSAutomated LC-MS host cell protein identification and quantitation, with high-risk HCPs flagged for review.